📩 Daily Stock Watchlist – 05/08/2025

Hello Investor,

Here’s your daily stock watchlist with key insights to help guide your investment decisions. Today’s report includes market trends, upcoming catalysts, and a spotlight on Acelyrin Inc. (SLRN), a clinical-stage biotech company advancing immunology therapies and navigating a high-stakes merger vote.

📈 Market Overview

• S&P 500: 5,150.23 (▲ 0.42%)

• Nasdaq Composite: 16,320.45 (▲ 0.58%)

• Dow Jones Industrial Average: 39,210.67 (▲ 0.35%)

Key Macro Notes:

• Labor Data Softens: Initial jobless claims ticked up to 240K, reinforcing expectations for a Fed rate pause this summer.

• Earnings Season Continues: Big names like Shopify and ConocoPhillips report today, with markets watching for signals on consumer strength and global demand.

• Trump to Unveil Trade Deal: President Trump will announce a new U.S.-UK trade agreement, with potential implications for autos, steel, and tech.

🏆 Stock Spotlight: Acelyrin Inc. (SLRN)

Acelyrin Inc. is a California-based biopharmaceutical company focused on developing therapies for immune-mediated diseases. With an evolving late-stage pipeline and a pending strategic merger, SLRN is one to watch.

Why It Matters Now:

• Merger With Alumis Inc.: Shareholders are set to vote May 13 on combining with Alumis to form a stronger late-stage immunology pipeline.

• Rejected Takeover Offer: Concentra Biosciences submitted an unsolicited acquisition offer, which Acelyrin declined in favor of the Alumis merger.

• Strong Cash Position: Post-merger, the combined entity would hold ~$737M in cash—a major runway for advancing pipeline assets.

Key Levels for Investors:

• Accumulation Zone: $2.00–$2.50

• Growth Target (6–12 mo): $8.00–$8.40

• Support Level: $1.80

Catalysts to Watch:

• May 13 Shareholder Vote: Approval would reshape the company’s strategic path.

• Q1 Earnings (Expected May 15): Look for updates on financials and pipeline progress.

• Pipeline Milestones: Further updates on lonigutamab for thyroid eye disease and izokibep for HS and PsA could move sentiment.

Risks:

• Merger Uncertainty: Legal scrutiny around the merger and shareholder alignment remain key variables.

• Clinical Trial Risk: Pipeline success remains speculative at this stage.

• Biotech Volatility: Broader market sentiment shifts can heavily impact small-cap biotech valuations.

Institutional & Insider Activity:

• Institutional Ownership: 87.3% — Major holders include T. Rowe Price and Vanguard.

• Insider Transactions: CEO Mina Kim sold $49,353 in shares last month, worth monitoring for sentiment trends.

• Options Activity: No unusual volume noted recently.

📅 Earnings & Market Events to Watch

Thursday, May 8, 2025 – Shopify (SHOP), ConocoPhillips (COP), and Warner Bros. Discovery (WBD) Earnings

• Focus on: Key reports across e-commerce, energy, and media sectors will offer insights into consumer demand and ad spend trends.

Thursday, May 8, 2025 – U.S. Initial Jobless Claims

• Focus on: Labor market softness could reinforce expectations for a Fed rate pause or cut later this summer.

Thursday, May 8, 2025 – President Trump Announces U.S.-UK Trade Deal

• Focus on: The announcement of a new trade agreement may impact sectors like autos, steel, and digital services.

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Disclaimer: This newsletter is for informational purposes only and does not constitute financial advice. Always conduct your own research before making investment decisions.